Mechanical GPCR Activation by Traction Forces Exerted on ReceptorN-Glycans
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چکیده
منابع مشابه
Traction forces exerted by epithelial cell sheets.
Whereas the adhesion and migration of individual cells have been well described in terms of physical forces, the mechanics of multicellular assemblies is still poorly understood. Here, we study the behavior of epithelial cells cultured on microfabricated substrates designed to measure cell-to-substrate interactions. These substrates are covered by a dense array of flexible micropillars whose de...
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We have developed a new approach to detect mechanical forces exerted by locomoting fibroblasts on the substrate. Cells were cultured on elastic, collagen-coated polyacrylamide sheets embedded with 0. 2-micrometer fluorescent beads. Forces exerted by the cell cause deformation of the substrate and displacement of the beads. By recording the position of beads during cell locomotion and after cell...
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Successful prey capture by aquatic suction feeders depends on the ability of the predator to generate a flow of water external to the mouth that overcomes any movements and forces that the prey uses to resist the suction flow. Elucidating the nature and magnitude of these forces is a key to understanding what limits suction feeding performance. We identify three potential forces produced by the...
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ژورنال
عنوان ژورنال: ACS Pharmacology & Translational Science
سال: 2020
ISSN: 2575-9108,2575-9108
DOI: 10.1021/acsptsci.9b00106